Research Project in Vietnam
On going projects
๐ Lovastatin for adult patients with dengue:
protocol for a randomised controlled trial.
Dengue is the most
important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations
from asymptomatic infection through to life-threatening shock and haemorrhage.
One of the hallmarks of severe dengue is vascular endothelial disruption. There
is currently no specific therapy and clinical management is limited to
supportive care. Statins are a class of drug initially developed for lipid
lowering. There has been considerable recent interest in their effects beyond
lipid lowering. These include anti-inflammatory effects at the endothelium. In
addition, it is possible that lovastatin may have an anti-viral effect against
dengue. Observational data suggest that the use of statins may improve outcomes
for such conditions as sepsis and pneumonia. This paper describes the protocol
for a randomised controlled trial investigating a short course of lovastatin
therapy in adult patients with dengue.
Please see trial protocal here.
Project Leader: James Whitehorn